Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.7
USERS' SCORE
Good
Based on 65 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid benefits cholesterol
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Read More
9
DHA lowers cholesterol; boosts metabolism
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
9
Eicosapentaenoic acid reduces cholesterol inflammation
We explored how eicosapentaenoic acid (EPA) affects cholesterol levels and the risk of type 2 diabetes (T2D). Our study focused on individuals with high levels of atherogenic lipoproteins, specifically apoB, which are known to predict higher diabetes risk. Over a twelve-week period, participants received daily doses of EPA and docosahexaenoic acid (DHA) to see how these omega-3 fatty acids influenced the secretion of interleukin-1 beta (IL-1β) from human white adipose tissue (WAT).
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Read More
Most Useful Reviews
9
Decreased cholesterol levels
270 people found this helpful
I take this Omega-3 regularly! It’s very convenient that it contains all necessary fats in one capsule, which lasts a long time. I find 1 capsule daily sufficient. The large capsules are easy to swallow and have no smell. I haven’t experienced any side effects; rather, I feel much better, my nails no longer peel, my skin has cleared up, and my hair loss has reduced. Notably, my cholesterol levels have decreased. This Omega obviously works well for me, and I really appreciate it.
Read More
9
Normal cholesterol achieved
205 people found this helpful
Chic omega delivers a good dosage in one capsule! My mother’s cholesterol was elevated, but after taking it, everything returned to normal. I wholeheartedly recommend this product for its quality!
Read More
9
Cholesterol levels dropped
202 people found this helpful
This omega is incredible! I've found the quality to be exceptional, ensuring healthy blood vessels. My grandmother had high cholesterol, but after she started taking it, her levels began to drop. The packaging is also impressive!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.7
- All Researches
9
We explored the effects of eicosapentaenoic acid (EPA) from Antarctic krill oil (ESKO) on cholesterol levels and obesity-related conditions. Through a carefully designed study involving mice on a high-fat diet, we wanted to see if ESKO could improve cholesterol metabolism and reduce fat accumulation.
We found that diets high in fat significantly increased oxidative stress and indicators associated with obesity. However, supplementation with ESKO appeared to counteract these negative effects, helping to reduce fat buildup and improve cholesterol levels.
Specifically, ESKO improved important metabolic pathways and reduced the activity of certain proteins that typically promote high cholesterol. This suggests that eicosapentaenoic acid from krill oil could play a crucial role in tackling high cholesterol and obesity-related disorders.
We found that diets high in fat significantly increased oxidative stress and indicators associated with obesity. However, supplementation with ESKO appeared to counteract these negative effects, helping to reduce fat buildup and improve cholesterol levels.
Specifically, ESKO improved important metabolic pathways and reduced the activity of certain proteins that typically promote high cholesterol. This suggests that eicosapentaenoic acid from krill oil could play a crucial role in tackling high cholesterol and obesity-related disorders.
Read More
9
Eicosapentaenoic acid reduces cholesterol inflammation
We explored how eicosapentaenoic acid (EPA) affects cholesterol levels and the risk of type 2 diabetes (T2D). Our study focused on individuals with high levels of atherogenic lipoproteins, specifically apoB, which are known to predict higher diabetes risk. Over a twelve-week period, participants received daily doses of EPA and docosahexaenoic acid (DHA) to see how these omega-3 fatty acids influenced the secretion of interleukin-1 beta (IL-1β) from human white adipose tissue (WAT).
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Read More
9
We examined the impact of a highly purified eicosapentaenoic acid (EPA) formulation on cholesterol levels and overall heart health in individuals considered at high risk for cardiovascular issues. The study involved 226 patients who had high triglycerides and one or more cardiovascular risk factors, such as hypertension or diabetes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
Read More
9
Eicosapentaenoic acid benefits cholesterol
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Read More
9
DHA lowers cholesterol; boosts metabolism
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
User Reviews
USERS' SCORE
Good
Based on 65 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Decreased cholesterol levels
270 people found this helpful
I take this Omega-3 regularly! It’s very convenient that it contains all necessary fats in one capsule, which lasts a long time. I find 1 capsule daily sufficient. The large capsules are easy to swallow and have no smell. I haven’t experienced any side effects; rather, I feel much better, my nails no longer peel, my skin has cleared up, and my hair loss has reduced. Notably, my cholesterol levels have decreased. This Omega obviously works well for me, and I really appreciate it.
Read More
9
Normal cholesterol achieved
205 people found this helpful
Chic omega delivers a good dosage in one capsule! My mother’s cholesterol was elevated, but after taking it, everything returned to normal. I wholeheartedly recommend this product for its quality!
Read More
9
Cholesterol levels dropped
202 people found this helpful
This omega is incredible! I've found the quality to be exceptional, ensuring healthy blood vessels. My grandmother had high cholesterol, but after she started taking it, her levels began to drop. The packaging is also impressive!
Read More
9
Cholesterol dropped!
126 people found this helpful
An amazing omega! Each capsule contains the required amount of omega-3 acids, and my family and I take it regularly due to our limited fish consumption. The results are outstanding, and most importantly, my cholesterol has dropped! Highly recommend!
Read More
9
Reduced bad cholesterol
103 people found this helpful
Perfect value for money! These capsules, which are large yet lemon-flavoured and devoid of a fishy taste, have improved my skin, and after two weeks, my mother noted a reduction in her bad cholesterol levels. With a positive result in her tests after taking two capsules daily for three months, I am pleased with this purchase!
Read More
Frequently Asked Questions
10
Statin alternative effective
11 people found this helpful
With angina, my LDL cholesterol dropped from 130 to 65 in a month of taking this fish oil daily, alongside light exercise and a dairy-free diet. Even my doctor was impressed with the results, preferring it over statins.
9
Lowered cholesterol successfully
10 people found this helpful
I needed to manage my bad cholesterol, which had reached 180, risking serious health issues. After researching, I adopted a Mediterranean diet, increased my activity, and continued this supplement. Remarkably, in four months, my cholesterol level dropped to 124. I will keep up my efforts to maintain this improvement.
9
Reduced bad cholesterol
103 people found this helpful
Perfect value for money! These capsules, which are large yet lemon-flavoured and devoid of a fishy taste, have improved my skin, and after two weeks, my mother noted a reduction in her bad cholesterol levels. With a positive result in her tests after taking two capsules daily for three months, I am pleased with this purchase!
9
Cholesterol level improved
13 people found this helpful
During a health examination in January 2021, I was diagnosed with dyslipidemia and high cholesterol at 190. I didn’t change my routine for over six months, but while researching treatments, I decided to try this supplement. To my surprise, my January 2022 results showed my cholesterol had dropped to 113. I plan to continue taking it alongside my meals for ongoing benefits.
9
Significant triglyceride drop
4 people found this helpful
Recommended high-concentration fish oil. This fish oil Omega 3 has as much as 1040 mg and is IFOS 5-star certified, ensuring its quality. After my mother took this high-concentration fish oil, her triglycerides dropped from 190 to 110. The effect was remarkable. It's an excellent medicinal grade product.
9
Decreased cholesterol levels
270 people found this helpful
I take this Omega-3 regularly! It’s very convenient that it contains all necessary fats in one capsule, which lasts a long time. I find 1 capsule daily sufficient. The large capsules are easy to swallow and have no smell. I haven’t experienced any side effects; rather, I feel much better, my nails no longer peel, my skin has cleared up, and my hair loss has reduced. Notably, my cholesterol levels have decreased. This Omega obviously works well for me, and I really appreciate it.
7.5
Decreased bad cholesterol
6 people found this helpful
My bad cholesterol decreased from 148 to 128 after my November health checkup. I was advised against medication due to my age and started taking vitamins instead. After a month without improvement, I switched to this omega-3 product, taking one capsule nightly. At my August re-examination, my cholesterol had improved to 129. Despite the cost, I intend to keep using it.
9
We examined the impact of a highly purified eicosapentaenoic acid (EPA) formulation on cholesterol levels and overall heart health in individuals considered at high risk for cardiovascular issues. The study involved 226 patients who had high triglycerides and one or more cardiovascular risk factors, such as hypertension or diabetes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
8
We examined the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on high cholesterol levels. In a systematic review of randomized controlled trials, we looked at studies involving at least 2 grams of EPA or its counterpart, docosahexaenoic acid (DHA).
Both EPA and DHA were found to lower triglyceride levels, with DHA appearing slightly more effective. Interestingly, we also saw that DHA increases high-density lipoprotein (HDL) cholesterol, which is known to promote heart health, while EPA does so as well, but to a lesser extent.
On the flip side, DHA has been observed to increase low-density lipoprotein (LDL) cholesterol, but it also enhances the size of LDL particles, making them less likely to contribute to artery blockages. Moreover, we noted that DHA might be more effective than EPA in reducing heart rate and blood pressure, which are essential factors in heart health.
Although both EPA and DHA show potential in promoting heart health by reducing inflammation and oxidative stress, the variations in their effects can make things complicated. We found that the evidence comparing EPA and DHA directly is limited, and more high-quality research is necessary to better understand their individual impacts on cholesterol and other cardiovascular risk factors.
Overall, while EPA has beneficial effects on cholesterol, further studies are needed to isolate these effects clearly from those of DHA.
Both EPA and DHA were found to lower triglyceride levels, with DHA appearing slightly more effective. Interestingly, we also saw that DHA increases high-density lipoprotein (HDL) cholesterol, which is known to promote heart health, while EPA does so as well, but to a lesser extent.
On the flip side, DHA has been observed to increase low-density lipoprotein (LDL) cholesterol, but it also enhances the size of LDL particles, making them less likely to contribute to artery blockages. Moreover, we noted that DHA might be more effective than EPA in reducing heart rate and blood pressure, which are essential factors in heart health.
Although both EPA and DHA show potential in promoting heart health by reducing inflammation and oxidative stress, the variations in their effects can make things complicated. We found that the evidence comparing EPA and DHA directly is limited, and more high-quality research is necessary to better understand their individual impacts on cholesterol and other cardiovascular risk factors.
Overall, while EPA has beneficial effects on cholesterol, further studies are needed to isolate these effects clearly from those of DHA.
8
Omega-3s improve cholesterol and vascular health
We conducted a study to evaluate how high-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) might affect cholesterol levels, particularly remnant-like lipoprotein cholesterol (RLP-C), and the ankle-brachial index (ABI) in hemodialysis patients struggling with dyslipidemia. Our research involved 38 participants who were divided into two groups: one received standard therapy alone, while the other received the same therapy plus the omega-3 supplements for three months. After the intervention, we took a closer look at how these treatments influenced cholesterol levels and vascular health.
The results were quite promising for those on the omega-3 regimen. The group that received EPA/DHA showed a significant reduction in RLP-C levels, with an average drop of about 3.25 mg/dL. In contrast, the control group experienced a small increase in cholesterol levels. Additionally, the omega-3 group also saw improvements in ABI measurements, indicating better peripheral arterial function. We discovered a noteworthy correlation, showing that the drops in cholesterol were connected to improvements in ABI.
In light of these findings, it appears that adding EPA/DHA can enhance standard treatment options for hemodialysis patients by lowering harmful cholesterol levels and improving vascular health. This suggests that healthcare providers should pay attention to RLP-C levels in these patients and consider omega-3 fatty acids as a viable option for managing cardiovascular risks.
The results were quite promising for those on the omega-3 regimen. The group that received EPA/DHA showed a significant reduction in RLP-C levels, with an average drop of about 3.25 mg/dL. In contrast, the control group experienced a small increase in cholesterol levels. Additionally, the omega-3 group also saw improvements in ABI measurements, indicating better peripheral arterial function. We discovered a noteworthy correlation, showing that the drops in cholesterol were connected to improvements in ABI.
In light of these findings, it appears that adding EPA/DHA can enhance standard treatment options for hemodialysis patients by lowering harmful cholesterol levels and improving vascular health. This suggests that healthcare providers should pay attention to RLP-C levels in these patients and consider omega-3 fatty acids as a viable option for managing cardiovascular risks.
8
Icosapent ethyl reduces cardiovascular events
We examined the effects of icosapent ethyl, a form of eicosapentaenoic acid, on patients with high cholesterol, specifically those who also have elevated triglyceride levels. In this analysis of the REDUCE-IT trial, we focused on statin-treated individuals who had a high risk of cardiovascular problems and found that the treatment could lower the occurrence of serious cardiovascular events.
The study included a significant number of patients who were divided based on their low-density lipoprotein cholesterol (LDL-C) levels. An interesting finding was that icosapent ethyl appeared to benefit both groups—those with LDL-C levels below 55 mg/dL and those with levels at or above 55 mg/dL. For patients with very well-controlled cholesterol, the treatment resulted in a lower rate of cardiovascular issues compared to a placebo, indicating its effectiveness even among those managing their cholesterol well.
While we did find that icosapent ethyl could help manage cardiovascular risks in patients with heightened cholesterol, it's essential to clarify that the study primarily focused on the rate of cardiovascular events rather than a direct impact purely on cholesterol levels. Overall, our findings suggest that even patients with optimal cholesterol control can still gain benefits from this treatment regarding cardiovascular health.
The study included a significant number of patients who were divided based on their low-density lipoprotein cholesterol (LDL-C) levels. An interesting finding was that icosapent ethyl appeared to benefit both groups—those with LDL-C levels below 55 mg/dL and those with levels at or above 55 mg/dL. For patients with very well-controlled cholesterol, the treatment resulted in a lower rate of cardiovascular issues compared to a placebo, indicating its effectiveness even among those managing their cholesterol well.
While we did find that icosapent ethyl could help manage cardiovascular risks in patients with heightened cholesterol, it's essential to clarify that the study primarily focused on the rate of cardiovascular events rather than a direct impact purely on cholesterol levels. Overall, our findings suggest that even patients with optimal cholesterol control can still gain benefits from this treatment regarding cardiovascular health.
5
We conducted a study to explore the impact of eicosapentaenoic acid (EPA) supplementation on various health issues among maintenance hemodialysis patients, particularly focusing on its effects on cholesterol levels. In this randomized, placebo-controlled trial, 60 patients suffering from severe pruritus were divided into two groups. One group received 1000 mg of fish oil containing over 900 mg of EPA, while the other group took 1000 mg of soybean oil twice daily for three months.
Throughout the study, we observed notable changes in cholesterol levels among those taking EPA. While there were reductions in total cholesterol and triglyceride levels in the treatment group, it was noted that high-density lipoprotein (HDL) levels decreased as well. Although EPA showed potential benefits in lowering certain types of cholesterol, the decrease in HDL may raise concerns since HDL is often referred to as "good" cholesterol.
Overall, our findings suggest that while EPA can have positive effects on cholesterol management, particularly in reducing harmful types, it is essential to examine these effects carefully. There was also improvement in skin moisture and depressive symptoms among patients taking EPA, highlighting the compound's broad health effects beyond just cholesterol levels.
Throughout the study, we observed notable changes in cholesterol levels among those taking EPA. While there were reductions in total cholesterol and triglyceride levels in the treatment group, it was noted that high-density lipoprotein (HDL) levels decreased as well. Although EPA showed potential benefits in lowering certain types of cholesterol, the decrease in HDL may raise concerns since HDL is often referred to as "good" cholesterol.
Overall, our findings suggest that while EPA can have positive effects on cholesterol management, particularly in reducing harmful types, it is essential to examine these effects carefully. There was also improvement in skin moisture and depressive symptoms among patients taking EPA, highlighting the compound's broad health effects beyond just cholesterol levels.
8
We assessed the effectiveness of omega-3-acid ethyl acetate, which includes docosahexaenoic acid (DHA), in managing high cholesterol, particularly focusing on patients with severe hypertriglyceridemia. In a carefully designed randomized, double-blind, placebo-controlled study, 239 participants were assigned to receive either omega-3 capsules or a placebo for 12 weeks.
Throughout the study period, we measured various cholesterol-related indicators at the start and after 4, 8, and 12 weeks. We observed significant reductions in triacylglycerols, total cholesterol, non-high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein C-III in the omega-3 group compared to the placebo. These findings suggest that the combined omega-3 treatment, which prominently features DHA, can enhance lipid profiles in patients struggling with severe hypertriglyceridemia.
However, it’s important to note that there was no significant change observed in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or the LDL-C/HDL-C ratio between the two groups. Furthermore, the safety profile was similar across both groups, indicating that omega-3 capsules are generally well-tolerated. Overall, while DHA is part of the treatment, we could not isolate its specific impact on cholesterol levels due to the study’s design, which considered the effects of the omega-3 formulation collectively.
Throughout the study period, we measured various cholesterol-related indicators at the start and after 4, 8, and 12 weeks. We observed significant reductions in triacylglycerols, total cholesterol, non-high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein C-III in the omega-3 group compared to the placebo. These findings suggest that the combined omega-3 treatment, which prominently features DHA, can enhance lipid profiles in patients struggling with severe hypertriglyceridemia.
However, it’s important to note that there was no significant change observed in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or the LDL-C/HDL-C ratio between the two groups. Furthermore, the safety profile was similar across both groups, indicating that omega-3 capsules are generally well-tolerated. Overall, while DHA is part of the treatment, we could not isolate its specific impact on cholesterol levels due to the study’s design, which considered the effects of the omega-3 formulation collectively.
References
- Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
- Uthaiah NM, Venkataramareddy SR, Mudhol S, Sheikh AY. EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats. Food Res Int. 2025;202:115733. doi:10.1016/j.foodres.2025.115733
- Yoshikiyo K, Shimizu H, Nagato EG, Ishizuka S, Yamamoto T. Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels. Molecules. 2025;30. doi:10.3390/molecules30020281
- Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16213614
- Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. doi:10.1038/s41598-024-73672-6
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
- Bashir B, Schofield J, Downie P, France M, Ashcroft DM, et al. Beyond LDL-C: unravelling the residual atherosclerotic cardiovascular disease risk landscape-focus on hypertriglyceridaemia. Front Cardiovasc Med. 2024;11:1389106. doi:10.3389/fcvm.2024.1389106
- Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. doi:10.3389/fneph.2024.1365809
- Omari M, Alkhalil M. Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies. J Cardiovasc Dev Dis. 2024;11. doi:10.3390/jcdd11040126
- Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, et al. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. J Am Coll Cardiol. 2024;83:1529. doi:10.1016/j.jacc.2024.02.016
- Liakos CI, Lanaras L, Bristianou M, Papadopoulos DP. Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals. Lipids. 2024;59:67. doi:10.1002/lipd.12391
- Ganuza E, Etomi EH, Olson M, Whisner CM. Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population. Front Nutr. 2024;11:1293909. doi:10.3389/fnut.2024.1293909
- Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. doi:10.3390/medicina60010075
- Mueller PA, Bergstrom P, Rosario S, Heard M, Pamir N. Fish Oil Supplementation Modifies the Proteome, Lipidome, and Function of High-Density Lipoprotein: Findings from a Trial in Young Healthy Adults. J Nutr. 2024;154:1130. doi:10.1016/j.tjnut.2024.01.007
- Kaur G, Mason RP, Steg PG, Bhatt DL. Omega-3 fatty acids for cardiovascular event lowering. Eur J Prev Cardiol. 2024;31:1005. doi:10.1093/eurjpc/zwae003
- Chang Y, Xuan Y, Zhang R, Ding X, Zeng Q, et al. Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents. Animals (Basel). 2024;15. doi:10.3390/ani15010021
- Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. doi:10.1039/d4fo04961f
- Coelho-Júnior HJ, Álvarez-Bustos A, Picca A, Calvani R, Rodriguez-Mañas L, et al. Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults. Nutrients. 2024;16. doi:10.3390/nu16234087
- Cabrita ARJ, Barroso C, Fontes-Sousa AP, Correia A, Teixeira L, et al. Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota. Front Vet Sci. 2024;11:1449141. doi:10.3389/fvets.2024.1449141
- Zhang D, Wang Z, Guo S, Sun Y, Zhou D, et al. F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol. Exp Gerontol. 2024;196:112577. doi:10.1016/j.exger.2024.112577
- Zhao W, Wang Y, Li J, Chen T, Yin D, et al. Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study. Lipids. 2024;59:145. doi:10.1002/lipd.12406
- Li P, Khan S, Huang Y, Lu S, Zhou P, et al. Effect of Perilla seeds inclusion on the performance, egg quality characteristics, biochemical parameters and egg yolk fatty acid composition of laying hens. Trop Anim Health Prod. 2024;56:147. doi:10.1007/s11250-024-03983-3
